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分子影像中心实验室

江苏省“科教强卫工程”核医学医学创新团队

 

    中心主任:杨  敏,博士,研究员,博导

    主要成员:徐宇平,副研究员,硕导,课题组长(PI)

           潘栋辉,副研究员,课题组长(PI)

           严骏杰,助理研究员,博士,课题组长(PI)

              王辛宇,助理研究员,博士,课题组长(PI)

    科技奖励:获无锡市科技进步一等奖(2017)、中国商业联合会科技进步三等奖(2017)、第四届江苏医药科技进步二等奖(2017)、江苏省药理学会科技进步一等奖(2017)、河北医学科技一等奖(2017)、江苏省医学新技术引进一等奖(2017)、教育部科技进步一等奖(2012)、江苏省科技进步二等奖(2008)、中华医学科技三等奖(2009)、中国实验动物学会科技三等奖(2014)、中国抗癌协会科技三等奖(2011)、省新技术引进一等奖(2008)、省新技术引进二等奖(2014, 2009)、无锡市科技进步一等奖(2007)、南京市科技进步二等奖(2013)、第13届江苏省青年科技奖暨江苏省十大青年科技之星(2012)、世界核医学与生物学联盟优秀青年学者奖(2006)、首届肖伦青年科技奖(2008)、SNM青年学者奖(2011)等多项奖励。


    专  利:获中国发明专利证书25张,授权实用新型专利10项。

 

    承担科研项目简介:

    1. PM2.5模拟粒子携带重金属及放射性对机体的损伤及防护研究(国家自然基金,2017-2020)

    2. 帕金森病早期诊断生物标记及综合诊断指标体系研发(国家重点研发计划“重大慢性非传染性疾病防控研究”重点专项,2016-2020)

    3. 基于同位素示踪技术的抗肿瘤药物临床评价技术平台的建设(十三五重大新药专项,2017-2020)

    4. 胰高血糖素样肽-1受体PET显像技术在神经内分泌肿瘤诊疗中的应用研究(省科技支撑计划,2016-2019)

    5. 自组装PET/MR/PA 三模式纳米探针的构建及在转铁蛋白受体高表达肿瘤中的应用(国家自然基金,2015-2018)

    6. 新型靶向HER2分子影像探针用于乳腺癌诊治的基础研究(国家自然基金,2015-2018)

    7. 新型FSHR靶向探针18F-X-FSH33-53的研制及在前列腺癌诊断中的应用研究(国家自然基金,2015-2017)

    8. 新型多氮杂环双功能螯合剂的研发及在Al18F标记中的应用研究(国家自然基金,2015-2017)

    9. 新型酶催化ugi三组分反应物理法诱导合成功能性环肽的研究(国家自然基金,2016-2018)

    10. 靶向GRPR的铁蛋白笼状嵌合体多功能分子探针的构建及其PET/MRI/NIRF三模式显像的探索研究(国家自然基金,2012-2015)

    11. GLP-1受体特异性正电子显像剂18F-FBEM-cys40-exenatide的研制及在胰岛素瘤显像中的应用研究(国家自然基金,2012-2014)

    12. 肿瘤诊断试剂18F-Al-NOTA-MATBBN的研制(省科技支撑计划,2014-2017)

    13. PET新制剂氟[18F]-铝-匹仑吉肽及其配套试剂盒的研制(省科技支撑计划, 2012-2015)

    14. 毒性生物标志物与人源化动物模型关键技术研究(十二五重大新药专项子课题,2012-2015)

 

    社会任职及荣誉称号:

    1.享受国务院政府特殊津贴

    2.江苏省突出贡献中青年专家

    3.江苏省留学回国先进个人

    4.江苏医药科技杰出青年奖

    5.江苏省医学创新团队领军人才(2016-2020)

    6.江苏省十大青年科技之星

    7.中华医学会核医学分会第二届“68Ga显像与精准诊疗”工作委员会副主委

    8.中国核学会核医学分会放射性药物与转化专业委员会副主任委员兼秘书长

    9.中国核学会核医学分会第八届理事会理事及放射性药物与实验核医学专业委员会主委

    10.中华医学会核医学分会第八、九届委员会青年委员

    11.中国生物物理学会分子影像学专业委员会第一届青年委员、辐射与环境专业委员会委员

‍‍    12.江苏省“333高层次人才培养工程”第二层次培养对象(突出贡献奖表彰)

    13.江苏省“六大人才高峰”高层次人才

    14.江苏省“科教兴卫工程”医学重点人才(考核等级 优秀)

    15.国家科技奖励、国家自然基金委等项目评审专家

    16.国内外多家杂志编委、审稿人(ACS Nano, Biomaterials et al)‍‍‍‍



 

    配套设施

 

    代表性论文:

1.PET Imaging of FSHR Expression in Tumors with 68Ga-Labeled FSH1 Peptide. Contrast Media & Molecular Imaging,  2017,DOI: 10.1155/2017/2674502. (i f: 3.13)
2.PET of HER2 Expression with a Novel 18FAl Labeled Affibody. Journal of Cancer, 2017, 8(7):1170-1178 (i f: 3.609)
3.One-Pot Synthesis of Soluble and Fluorescent Aliphatic Hyperbranched Poly(Amide-Imide) with Solvent-Dependent Emission. Journal of Polymer Science Part A-Polymer Chemistry,2017, 55, 2053–2060.(i f 2.952)
4.An Investigation on a Novel Anti-tumor Fusion Peptide of FSH33-53-IIKK. Journal of Cancer,2016, 7(8):1010-1019. (i f: 3.609)
5.Thiolactone-maleimide: a functional monomer to synthesize fluorescent aliphatic poly(amide-imide) with excellent solubility via in situ PEGylation. Polymer Chemistry, 2016,7: 6241-6249. (i f 5.687)
6.Melanin nanoparticles as an endogenous agent for efficient iron overload therapy. Journal of Materials Chemistry B, 2016,4:7233- 7240.(i f 4.872)
7.Prostate cancer imaging of FSHR antagonist modi fied with a hydrophilic linker. Contrast Media Mol Imaging, 2016,11(2):99-105 (i f 3.286)
8.Dragon fruit-like biocage as an iron trapping nanoplatform for high efficiency targeted cancer multimodality imaging. Biomaterials, 2015,69(11):30-37.(i f 8.557)
9.Unexpected fluorescence from dithio/amino-succinimides containing polymers. Polymer Chemistry, 2015,34(6):6133-6139 (i f 5.520)
10.Engineering melanin nanoparticles as an efficient drug-delivery system for imaging-guided chemotherapy. Adv Mater, 2015,27(34):5063-9(i f 17.493)
11.Pilot Prospective Evaluation of 18F-Alfatide II for Detection of Skeletal Metastases. Theranostics,2015,5(10):1115-21. (i f 8.022)
12.18F-Alfatide II PET/CT in healthy human volunteers and patientswith brain metastases. Eur J Nucl Med Mol Imaging,2015,42(13):2021-2028. (i f 5.383)
13.PET of Follicle-Stimulating Hormone Receptor: Broad Applicability to Cancer Imaging. Mol Pharmaceutics ,2015,12(2):403-410.(i f 4.384)
14.Surface Functionalization of Chemically Reduced Graphene Oxide for Targeted Photodynamic Therapy.J Biomed Nanotechnol ,2015, 11(1): 117-125 (i f 7.578)
15.Perylene-diimide-based nanoparticles as highly efficient photoacoustic agents for deep brain tumor imaging in living mice. Adv Mater, 2015,27(5):843-847(i f 17.493)
16.Transferring Biomarker into Molecular Probe: Melanin Nanoparticle as a Naturally Active Platform for Multimodality Imaging. J Am Chem Soc, 2014,136(43):15185-15194.(i f 12.113)
17.Insulinoma imaging with glucagon-like peptide-1 receptor targeting probe 18F-FBEM-Cys39-exendin-4.J Cancer Res Clin Oncol, 2014,140 (9): 1479-1488(i f 3.009)
18.A new 68Ga-labeled BBN peptide with a hydrophilic linker for GRPR targeted tumor imaging. Amino Acids, 2014,46(6):1481-1489 (i f 3.914)
19.Pilot Study of a Novel 18F-Labeled FSHR Probe for Tumor Imaging. Molecular Imaging Biology,2014,16(4):578-585 (i f 3.095)
20.PET imaging of prostate tumors with 18F-Al-NOTA-MATBBN. Contrast Media Mol Imaging, 2014,9(6):342-348. (SCI i f 3.333)
21.Biomimetic RNA-Silencing Nanocomplexes: Overcoming Multidrug Resistance in Cancer Cells. Angew Chem Int Edit, 2014,53(7):1997-2001. (i f 13.734)
22.Photosensitizer-conjugated silica-coated gold nanoclusters for fluorescence imaging-guided photodynamic therapy.Biomaterials, 2013,34(19):4643-4654.(SCI i f 7.6)
23.First Experience of [18F]AlF-NOTA-PRGD2 in Lung Cancer Patients Using A New Lyophilized Kit for Rapid Radiofluorination. J Nucl Med, 2013,54:691-698.(i f 5.8)
24.Highly Robust, Recyclable Displacement Assay for Mercuric Ions in Aqueous Solutions and Living Cells. ACS Nano, 2012, 6 (12):10999-11008.(i f 12.06)
25.Evaluation of fluorine-labeled gastrin-releasing peptide receptor (GRPR) agonists and antagonists by LC/MS. Amino Acids, 2012, 43(4):1625-1632. (i f 3.914)
26.Multiplexed PET Probes for Imaging Breast Cancer Early Response to VEGF121/rGel Treatment. Mol Pharm, 2011 ,8(2):621-628. (i f 5.4 )
27.PET Imaging Early Response to a Tyrosine Kinase Inhibitor ZD4190. Eur J Nucl Med Mol Imaging, 2011,38(7):1237-1247.(i f 5.036 )
28.18F-Labeled bombesin receptor agonist and antagonist: a comparative study in prostate cancer imaging. Theranostics, 2011,1(3):220-229 (i f 7.806)
29.Imaging tumor endothelial marker 8 using an (18)F-labeled peptide.Eur J Nucl Med Mol Imaging, 2011,38(10):1806-1815. (i f 5.036 )
30.HSA Coated Iron Oxide Nanoparticles as Drug Delivery Vehicles for Cancer Therapy. Mol Pharm, 2011,8(5):1669-1676. (i f 5.4 )
31.A New 18F-labeled BBN-RGD peptide heterodimer with a symmetric linker for prostate cancer imaging. Amino Acids, 2011,41(2):439-447. (i f 4.106 )
32.PET of Insulinoma using 18F-FBEM-EM3106B, a New GLP-1 Analog. Mol Pharm, 2011,8(5):1775-82. (i f 5.4 )
33.Evaluation of Chemotherapy Response in VX2 Rabbit Lung Cancer with 18F-Labeled C2A Domain of Synaptotagmin I. J Nucl Med, 2011, 52(4):592-599(i f 7.022 )
34.Chimeric ferritin nanocages for multiple function loading and multimodal imaging. Nano Lett, 2011,11(1):814-819(i f 12.186)
35.18F-FPPRGD2 and 18F-FDG PET imaging of Abraxane therapy response. J Nucl Med, 2011,52(1):140-146. (i f 7.022 )